Role of innate immune cells in inflammatory disorders
Host-Pathogen interactions
Medicinal plants of Himalayan region and their immune modulating capabilities
Bio-Sensors and medical devices
Education
Ph.D. 2008 Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Master's 2003 Biotechnology, Devi Ahilya University, Indore, MP, India
B.Sc(H) 2000 Biotechnology, Ranchi University, Ranchi, Jharkhand, India
Work Experience
Academic Research Experiences
Research fellow, Center for Immunology and Inflammatory Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA 02129 (2011- 2014)
Department of Pathology and lab medicine, Children’s Hospital, Harvard Medical School, Boston (2009-2011)
Academic Administrative Experience
Assistant Professor at IIT Mandi from Dec 2014
Industrial Experience
Trainee Bioinfomatics Scientist at Apticraft Systems Pvt Ltd, Indore 2003
Awards, Honors, and Invited Talks
Ramalingaswami Fellowship 2014 from Department.of Biotechnology, New Delhi, India
Ramanujan Fellowship 2014 from Department of Science and Technology, New Delhi, India
Prof. P. C. Sen Gold Medal for best paper in the year 2008
Best poster award for Mycology and Parasitology in the year 2008
“Pre-Doctoral Travel Award” from American Society for Cell Biology for the year 2007
Foreign Travel Award 2007, from Department of Science and Technology, New Delhi, India, to attend 47th Annual Meeting of American Society for Cell Biology, held at Washington, USA. 2007
Qualified GATE- 2003 (Graduate Aptitude Test for Engineering) in Life Sciences discipline with 99.47 Percentile (All India Rank 19th)
Qualified CSIR UGC NET 2003 for JRF in life sciences discipline
Publications
Journal Publications
Upadhyay A, Amanullah A, Chhangani D, Mishra R, Prasad A, Mishra A. Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms. Molecular Neurobiology 2015 Aug 9.PubMed PMID: 26255182
Singh AK, Singh SK, Singh A, Gupta KK, Khatoon J, Prasad A, Rai RP, Gupta RK, Tripathi M, Husain N, Prasad KN. 2015. Immune response to Taenia solium cyst after anti-parasitic therapy. Int. J. Parasitol. 45(12):749-59
Ramirez-Ortiz ZG*, Prasad A*, Griffith JW, Pendergraft WF, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK. 2015. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.Nature Immunology doi:10.1038/ni.3143. *Joint first author
Singh AK, Prasad KN, Prasad A, Tripathi M, Gupta RK, Husain N. 2013. Immune responses to viable and degenerative metacestodes of Taenia solium in naturally infected swine.Int. J. Parasitol. 43 (14):1101-7.
Ramirez-Ortiz ZG, Pendargraft WF, Prasad A, Byrne MH, Blanchette CJ, Luster AD, Hacohen N, El Khoury J, Means TK. 2013. The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity.Nature Immunology 14:917-26.*Joint first author
Jo H, Mondal S, Tan D, Nagata E, Takizawa S, Sharma AK, Hou Q, Shanmugasundaram K, Prasad A, Tung JK, Tejeda AO, Man H, Rigby AC, Luo HR. 2012. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc. Natl. Acad. Sci. U S A. 109 (26):10581-6
Prasad A*, Jia Y*, Chakraborty A, Jain SK, Zhong J, Roy SG, Loison F, Mondal S, Sakai J, Blanchard C, Snyder SH and Luo HR. 2011. Inositol hexakisphosphate kinase 1 (InsP6K1) is a key modulator of neutrophil function in innate immunity via negative regulation of PtdIns(3,4,5)P3 signaling. Nature Immunology 12:752-60
Li Y, Prasad A, Jia Y, Loison F, Mondal S, Silberstein LE, Ding S, Luo HR. 2011. Pre-treatment with PTEN inhibitor SF1670 augments the efficacy of neutrophil transfusion in a clinically relevant mouse neutrophil transfusion model. Blood 117:6702-6713
Prasad A, Prasad KN, Gupta RK, Tripathi S, Jha S, Paliwal VK, Tripathi M. 2011. Immune response to different fractions of Taenia solium cyst fluid antigens in patients with Neurocysticercosis. Exp. Parasitol. 127:687-92
Yadav A, Malik GK, Trivedi R, Prasad A, Nath K, Prasad KN, Agrawal P, Rathore RKS, Tripathi RP, Gupta RK. 2009. Correlation of CSF neuroinflammatory molecules with leptomeningeal cortical subcortical white matter fractional anisotropy in neonatal meningitis. Magn. Reson. Imaging. 27:214-221
Prasad KN, Prasad A, Gupta RK, Pathak KN, Pradhan S, Tripathi M, Pandey CM. 2009. Neurocysticercosis in patients with active epilepsy from a pig farming community. Trans. Roy. Soc. Trop. Med. Hyg. 103:144-150.
Prasad A, Prasad KN, Gupta RK, Pradhan S. 2009. Increased expression of ICAM-1 among the symptomatic NCC cases. J. Neuroimmunol. 206:118-120
Goyal A, Prasad A, Ghoshal U, Ayyagari A, Prasad KN. 2009. Extended spectrum β-lactamases in Escherichia coli & Klebsiella pneumoniae & associated risk factors. Indian J. Med. Res. 129:695-700
Prasad A, Prasad KN, Yadav A, Gupta RK, Pradhan S, Jha S, Tripathi M. 2008. Lymphocyte transformation test: A new method for diagnosis of neurocystierosis (NCC). Diagn. Microbiol. Infect. Dis. 61:198-202
Prasad A, Gupta RK, Pradhan S, Tripathi M, Pandey CM, Luthara G, Prasad KN. 2008. What triggers seizures in neurocysticercosis?- A MRI based study in pig farming community from a district of North India. Parasitol. Int. 55:166-171
Prasad KN, Prasad A, Verma A, Singh AK. 2008. Human Cysticercosis in India: A Review. J Biosciences 33: 571–582
Prasad KN, Prasad A, Verma A, Gupta RK, Pandey CM. 2008. Taenia solium taeniasis and neurocysticercosis (NCC): experience from North Indian pig farming community. Current Trends in Parasitology 13-20.
Dwivedi M, Mishra A, Prasad A, Azim A, Singh RK, Baronia AK, Prasad KN, Dwivedi UN. 2008. Aeromonas caviae septicemia in immunocompetent gastrointestinal carriers. Brazi. J. Infectious Dis. 12:547-548
Goyal A, Prasad A, Ghoshal U, Prasad KN. 2008. Comparison of disk diffusion, disk potentiation & double disk synergy methods for detection of extended spectrum beta lactamases in Enterobacteriaceae. Indian J. Med. Res. 128:209-211
Gupta RK, Nath K, Prasad A, Prasad KN, Husain M, Rathore RKS, Husain N, Srivastava C, Khetan P, Trivedi R, Narayana PA. 2008. In vivo demonstration of neuroinflammatory molecules expression in brain abscess with diffusion tensor imaging. AJNR Am. J. Neuroradiol. 29:326-332
Prasad KN, Prasad A, Gupta RK, Pandey CM, Uttam S. 2007. Prevalence and associated risk factors of T. solium taeniasis in a rural pig farming community of North India. Trans. Roy. Soc. Trop. Med. Hyg. 101: 1241-1247
Prasad KN, Chawla S, Prasad A, Tripathi M, Husain N, Gupta RK. 2006. “Clinical Signs for Identification of Neurocysticercosis in Swine Naturally Infected with Taenia solium”. Parasitol. Int. 55:151-154
Prasad A, Prasad KN, Gupta RK, Pradhan S, Jha S, Tripathi M. 2006. Identification of immuno dominant fractions of Taenia solium cyst fluid and its cytokine response. Ann. Neurosci. 13(s):109
Nucleotide sequence submitted to Genbank
Goyal A, Prasad A, Prasad KN. Extended spectrum beta lactamases in Enterobacteriaceae and associated risk factors. EU030434
Goyal A, Prasad A, Prasad KN. Extended spectrum beta lactamases in Enterobacteriaceae and associated risk factors. EF675749
Prasad A, Goyal A, Prasad KN. Extended spectrum beta lactamases in Enterobacteriaceae and associated risk factors. EU030435
Conferences and Symposia
Prasad A, Ramirez OZ, Means TK. Mechanism id AIM2 inflammasomes regulations. Immunology 2013, American Society for Immunology, Hawai, USA
Prasad A, Verma A, Gupta RK, Pradhan S, Jha S, Tripathi M, Husain M, Prasad KN. “Lymphocyte Proliferation Test: A New Method for Diagnosis of Neurocystierosis”. UP MICROCON-2008, 4th annual conference of UP chapter of the Indian Association of Medical Microbiologist (IAMM), at CSJMMU, Lucknow, India
Prasad A, Gupta RK, Pradhan S, Tripathi M, Prasad KN. “In vitro Immune Response of Low Molecular Taenia solium Cyst Fluid Antigens”. Presented in 47th Annual Meeting of American Society fro Cell Biology 2007(ASCB), Washington, USA., 1-5th December 2007
Prasad KN, Prasad A, Yadav A, Pradhan S, Jha S, Tripathi M, Gupta RK. “Lymphocyte Proliferation Test: A New Method for Diagnosis of Neurocystierosis”. Presented on 107th American Society of Microbiology 2007 (ASM), Toronto, Canada, 21st-25th May 2007
Prasad KN, Prasad A, Yadav A, Pradhan S, Jha S, Tripathi M, Gupta RK. “Lymphocyte Proliferation Test: A New Method for Diagnosis of Neurocystierosis”. Presented on 107th American Society of Microbiology 2007 (ASM), Toronto, Canada, 21st-25th May 2007
Prasad A, Prasad KN, Gupta RK, Pradhan S, Yadav A, Tripathi M, Pandey CM. “Low molecular weight T. solium cyst fluid fractions are immunodominant and induces Th1 immune response” Presented on National Congress of Parasitology, Kolkata; 27-29th Nov. 2006
Prasad A, Prasad KN, Pandey CM, Pradhan S, Gupta RK. “Identification of Diagnostic Markers in Pig Farming Community with Neurocysticercosis” MICROCON 2005, XXIX-Annual Conference of the Indian Association of Medical Microbiologist (IAMM), Chennai (Tamilnadu), India
Membership of professional socities
American Society for Immunology
American Society for Cell Biology
Indian Association of Medical Microbiology-UP Chapter
Opportunities for postdocs and research students
Our laboratory has openings for outstanding scholars who want to make career in understanding host-pathogen interaction or inflammation. Please drop us an email with your CV, contacts for 3 references, and brief outline of your work. If you have a specific question/ project you would like to work on in the lab please send single page summary of your research interest in the laboratory.
This laboratory is open to support suitable candidates with the right experience and expertise for the Early Career Fellowships for Ph.D.s, Research Fellowships for Masters and Summer Project Students. We will be happy to support outstanding candidates with our funding as well. If you are interested in the same please send a one-page outline of your proposal detailing how you are hoping to bring together your experience with the interests of the lab.