Prosenjit Mondal, Ph.D.

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Phone: 01905-237919
EMail: Prosenjit[at]iitmandi[dot]ac[dot]in
Address: School of Basic Sciences
IIT Mandi, PWD Rest House 2nd floor,
Near Bus Stand, Mandi - 175001
India

Research interests

  • Beta-Cell Biology and Insulin Secretion
  • Identifying the Molecular Mechanisms that Govern Pancreatic Beta-Cell Proliferation, Survival and Function in Normal Physiological and Pathophysiological Conditions of Diabetes Mellitus.
  • Development of Novel Agents Improves Survival and Function of Insulin Producing Pancreatic Beta Cells.
  • Diabetes and mitochondrial Bioenergetics

Education

  • Ph.D. in Life Sciences from Institute of Life Sciences, Bhubaneswar in 2008
  • M.Sc. in Biotechnology from Visva-Bharati University, Santiniketan
  • B.Sc. in Zoology from University of Calcutta

Work Experience

Academic Research Experience
Academic Administrative Experience
  • Assistant Professor, IIT Mandi, Himachal Pradesh, India, 2014 - Present

Teaching

  • IC 136 Understanding Biotechnology and its Applications (Odd Sem, 2018)
  • BY 510Advance Cell Biology (Odd Sem, 2018)
  • BY520PCell Biology and Physiology Lab (Odd Sem, 2018)
  • BY 503Cellular Fuel and Cellular Communication (Even Sem, 2018)
  • IC 136 Understanding Biotechnology and its Applications (Even Sem, 2018)
  • BY 524PMedical and NanoBiotechnology lab (Even Sem, 2018)
  • BY 526IPR and Biosafety (Even Sem, 2018)

Awards, Honors, and Invited Talks

  • International Travel Award 2014 Joint IUBMB-RCB Advanced School – 2014 Diabetes and Metabolic Syndrome, RCB India
  • Special Seminar series"Glucagon regulates hepatic kisspeptin to impair insulin secretion in diabetes mellitus."at Joint IUBMB-RCB Advanced School – 2014 Diabetes and Metabolic Syndrome, RCB India
  • Best Abstract Award 2014 Research Fest 2014, the Scripps Florida Society of Research Fellows’ (SF-SRF) fifth Scientific Symposium
  • Platform Presentation "The role of insulin decoy receptors in the pathogenesis of insulin resistance", Research Fest 2014, the Scripps Florida Society of Research Fellows’ (SF-SRF) fifth Scientific Symposium
  • PATENT -P. Mondal, M.Ray, S.Sahu, S.C.Sabat “A genetically modified recombinant rice plant Catalase-B, expressed in E.coli host that avoids light and temperature impairment” Application No.1180/KOL/07 of 27.08.07
  • Qualified GATE-2003
  • Qualified CSIR-UGC NET -2003

Publications

Journal Publications (published)
  • S Dogra, D Das, SK Maity, A Paul, P Rawat, PV Daniel, K. Das, S. Mitra, P.Chakraborty*, P.Mondal* (2022) Liver Derived  S100A6 Propels β Cell Dysfunction in NAFLD. Diabetes 71 (11), 2284-2296
  • K Girdhar, S Thakur, P Gaur, A Choubey, S Dogra, B Dehury, S Kumar, B Biswas, D K Dwivedi, S Ghosh, P Mondal* (2022) Design, synthesis, and biological evaluation of a small molecule oral agonist of the glucagon-like-peptide-1 receptor Journal of Biological Chemistry 01889 *Corresponding Author
  • B Biswas, S Dogra, G Dey, N A Murugan, P Mondal*, S Ghosh* (2022) Near-infrared emissive cyanine probes for selective visualization of the physiological and pathophysiological modulation of albumin levels Journal of Materials Chemistry B *Corresponding Author
  • PV Daniel, A Choubey, S Dogra, P Rawat, A S Khan, S Rajak, M Kamthan, P Mondal* (2021) NF-kB P65 regulates hepatic lipogenesis by promoting nuclear entry of ChREBP in response to a high carbohydrate diet. Journal of Biological Chemistry: 100714 *Corresponding Author
  • P Shitole, A Choubey, P Mondal*, R Ghosh (2021) Influence of low dose naltrexone on Raman assisted bone quality, skeletal advanced glycation end-products and nano-mechanical properties in type 2 diabetic mice bone Materials Science and Engineering: C 123 :112011
  • Choubey A, Girdhar K, Kar AK, Kushwaha S, Yadav MK, Ghosh D, P Mondal*. (2020) Low dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia Journal of Biological Chemistry Sep 17;jbc.RA120.013484. doi: 10.1074/jbc.RA120.013484 *Corresponding Author
  • Vineeth Daniel P, P Mondal* (2020) Causative and Sanative dynamicity of ChREBP in Hepato-Metabolic Disorders European Journal of Cell Biology, 151128 https://doi.org/10.1016/j.ejcb.2020.151128 *Corresponding Author
  • Martinez BA, Reis Rodrigues P, Nuñez Medina RM, P Mondal, et. al (2020) An alternatively spliced, non- signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans. Elife.Feb 25; 9: e49917.
  • Daniel PV, Kamthan M, Gera R, Dogra S, Gautam K Ghosh D, Mondal P (2019) Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces Hepatic Dyslipidemia. FEBS Lett. 2019 Jul 15. doi: 10.1002/1873-3468.13538 *Corresponding Author
  • Biswas, B; Dey, G, Dogra , S , Mukhopadhyay, A, Chowdhury, S, Mondal, P*, Ghosh, S (2019) Molecular Scale Optimum Hydrophobicity to Establish Enhanced Probe-Protein Interaction: Near-Infrared Imaging of Albumin Biosynthesis Modulation. ACS Applied Bio Materials (Accepted) *Corresponding Author
  • Dogra S, Kar AK, Girdhar K, Daniel PV, Chatterjee S, Choubey A, Ghosh S, Patnaik S, Ghosh D, Mondal P* (2019) Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis. Nanomedicine: Nanotechnology, Biology and Medicine 17: 210-222 *Corresponding Author
  • Girdhar K, Dehury B, Singh MK, Daniel VP, Choubey A, Dogra S, Kumar S, P. Mondal* (2018) Novel insights into the dynamics behavior of Glucagon-Like Peptide-1 Receptor with its small molecule Agonists. Journal of Biomolecular Structure and Dynamics,. 2018 Oct 8:1-23. doi: 10.1080/07391102.2018.1532818 *Corresponding Author
  • Kumar S, Ahmad K, Tandon G, Singh BU, Jha Y, Nagrale TD, Singh, KD, Girdhar K, P Mondal* (2018) Novel insight into the molecular interaction of catalase and sucrose: A combination of in silico and in planta assays study Computers and Electronics in Agriculture 151: 258-263 *Corresponding Author
  • P Mondal*, A Prasad, Khyati (2017) Interventions to improve β-cell mass and function. Ann Endocrinol (Paris) 2017 Oct;78(5):469-477. doi: 10.1016/j.ando.2016.11.002 *Corresponding Author
  • Dey, G ; Singh, Dewangan, J ; Daniel, P. V, Kamthan, M , Ghosh, D, Mondal, P *; Ghosh, S* (2017) Renal clearable new NIR probe: precise quantification of albumin in biofluids and fatty liver disease state identification through tissue specific high contrast imaging in vivo. Analytical Chemistry 2017 Sep 12. doi: 10.1021/acs.analchem.7b02187 *Corresponding Author
  • M L. Multhaup, M Seldin, A E. Jaffe, H Kirchner, X Lei, P. Mondal, Y Li, MA Hussain, A Drong, C Lindgren, M McCarthy,E Näslund, J R. Zierath, G. W Wong, A P. Feinberg (2015) Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metabolism 21(1) 138-149
  • P.Mondal*, W.J Song*, YY Li, K.S. Yang, M. A. Hussain (2014) Increasing beta-cell mass requires additional stimulation for adaptation to secretory demand. Molecular Endocrinology. 2014[Epub ahead of print] *Joint First Author
  • WJ. Song*, P. Mondal*, A Wolfe, L C.Alonso, B W. T. Ong, O C. Lim, K S. Yang, S Radovick, HJ.Novaira, E A. Farber, C R. Farber, S D. Turner, & MA. Hussain (2014) Glucagon regulates hepatic kisspeptin to impair insulin secretion in diabetes mellitus. Cell Metabolism 19(4):667–681 *Joint First Author
  • WJ. Song*, P. Mondal*,YY Li, SE Lee, MA. Hussain (2013) Pancreatic beta-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A Diabetes 62(8):2796-2807 *Joint First Author.
  • WJ. Song, M. Seshadri, U. Ashraf, T. Mdluli, P. Mondal, M. Keil, M. Azevedo, LS. Kirschner, CA. Stratakis, MA. Hussain (2011) Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metabolism
  • S. Diani-Moore, P. Ram, X. Li, P. Mondal, DY. Youn, AA. Sauve, AB. Rifkind (2010) Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect. J. Biol. Chem. 285(50):38801-38810
  • P. Mondal, M. Ray, S. Sahu, SC. Sabat (2008) Co-expression of GroEL/ES enhances the expression of plant catalase in bacterial cytosol. Protein Pept. Lett. 15(10): 1075-1078.
  • P. Mondal, M. Ray, M. Kar, SC. Sabat (2008) Molecular identification and properties of light –insensitive rice catalase-B express in E. coli. Biotechnol. Lett. 30: 563-568.
  • P. Mondal, N. Dey, AK. Dash, A. Chatterjee, BB. Sahu, B. Panda, IB. Maiti, SC. Sabat (2007) Structural and functional analysis of rice catalase-B gene promoter: presence of Dof and CAAT binding site. Plant Molecular Biology Reporter 25: 71 – 82
  • P. Nataraj, PB. Kavi Kishor, L. Ananda Reddy, P. Mondal, AK. Dash, M. Kar, S. Mohanty, SC. Sabat (2006) In silico modeling and hydrogen peroxide binding study of rice catalase. In Silico Biol. 6 (5): 435-447.
  • P. Mondal, SP Sinha Babu, NC Mandal (2005) Antimicrobial activity of saponins from Acacia auriculiformis. Fitoterapia 76: 462-465.

Conferences and Symposia

  • Poster : The role of insulin decoy receptors in the pathogenesis of insulin resistance, 2014 Joint IUBMB-RCB Advanced School – 2014 Diabetes and Metabolic Syndrome, RCB India
  • Poster: P. Mondal, W-J Song, Y. Li, M. Seshadri, MA. Hussain (2011) In vivo cyclin A2 over-expression is sufficient to drive β-cell proliferation. 2011 Mid-Atlantic Diabetes Research Symposium at National Institutes of Health, Bethesda, MD, USA
  • Poster: P. Mondal, W-J. Song, M. Seshadri, MA. Hussain, (2010) Protein kinase A signaling in hepatocytes inhibits ß-cell insulin secretion. 2010 Mid-Atlantic Diabetes Research Symposium at National Institutes of Health, Bethesda, MD, USA
  • Poster: W-J Song, M. Seshadri, P. Mondal, MA. Hussain, (2010) Cyclin A2 regulates pancreatic ß-cell size. 2010 Mid-Atlantic Diabetes Research Symposium at National Institutes of Health, Bethesda, MD, USA
  • Poster: M. Seshadri, W-J Song, P. Mondal, MA. Hussain, (2010) Disinhibition of cAMP-dependent Protein Kinase A potentiates glucose-stimulated insulin secretion via phosphorylation of the SNARE complex associated protein Snapin in mouse pancreas islets.

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