Dr. Rajanish Giri

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Phone: 01905-267134
EMail: rajanishgiri[at]iitmandi[dot]ac[dot]in
Address: School of Basic Sciences
Indian Institute of Technology Mandi
VPO Kamand, Mandi - 175005

We have opening of JRFs and postdocs, and candidates are encouraged to contact us

Research interests

  • Biophysics, Protein folding and Protein Engineering
  • Intrinsically Disordered Proteins
  • Alzheimer's Disease
  • Computational and Biophysical Study on Zika Virus (emphasis on Dark Proteome and Drug Discovery)


  • Ph.D.in Biochemistry from Sapienza University of Rome, Supervisor: Prof. Maurizio Brunori and Carlo Travaglini-Allocatelli, Italy in 2013
  • Master's in Biotechnology from Banaras Hindu University, Varanasi in 2007 ,
  • BSc in Chemistry and Botany from Allahabad University in 2005

Work Experience

Academic Research Experience
  • Assistant Professor, IIT Mandi, Himachal Pradesh, India 2015-till date
  • Postdoctoral Fellow at McMaster University, Hamilton, Canada (2013-2015)
  • Post-doctoral Fellowship from 'Istituto Pasteur-Fondazioni Cenci Bolognetti', Universita Degli Studi di Roma 'La Sapienza' with Prof. Maurizio Brunori (2012-2013)
  • Academic Teaching Experience

    • Course Taught: BY502 - Biophysics and Protein Engineering

      Professional Experience

      • F1000 Faculty Specialist
      • Membership: Indian Biophysical Society (life member)
      • Membership: Biophysical Society, USA (Till 2015)
      • Membership: American Chemical Society, USA (Till 2015)
      • Membership: The Protein Society, USA (Till 2015)

Awards, Honors, and Invited Talks

  • Associate, Indian Academy of Sciences, Bangalore (2017 to 2020)
  • Invited talk in the " 9th National Symposium cum Workshop on "Recent Trends in Structural Bioinformatics and Computer Aided Drug Design"[SBCADD'2017], Algappa University, Karaikudi, Tamilnadu, 14th –17th February, 2017.
  • Invited Talk in the "Bioprocessing India 2016" organized jointly by Center of Innovative and Applied Bioprocessing (CIAB), Mohali, Indian Institute of Science Education and Research (IISER), Mohali and Institute of Microbial Technology (IMTECH), Chandigarh. Mohali, December 15-17, 2016.
  • Invited Talk in the "International Conference on Current Trends in Biotechnology ICCB 2016”, VIT University, Vellore in association with The Biotech Research Society India (BRSI), VIT University, Vellore, December 8-10, 2016.
  • Invited in the "Third International Symposium on Protein Folding and Dynamics”, Organized at National Center for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, November 8-11, 2016.
  • Invited talk in the " International Conference on Translational Biotechnology (Biosangam 2016)", Organized at MNNIT Allhabad, 4-6 February, 2016.
  • Awarded DST SERB Young Scientist Scheme Grant, 2015.
  • Invited talk in the "Recent Developments in Medical Biotechnology and Structure-Based Drug Designing 2015 (RDMBSBDD-2015), IIT Guwahati Dates: 6-7 December, 2015".
  • Awarded DBT Travel Award to attend International Conference (Gordon Research Conference) on Proteins, Organized at New Hampshire, USA, 14-19 June, 2015.
  • Invited talk in the "5th Annual International Conference on Advances in Biotechnology (Biotech 2015)", Organized at IIT Kanpur, 13-15 March, 2015.
  • Invited talk in the National Symposium on Biophysics & Golden Jubilee Meeting of Indian Biophysical Society, New Delhi, India. (Organized by JMI, Central University, February 14-17, 2015).
  • Awarded with Protein Science Young Investigator Travel Grant / Protein Society Finn Wold Travel Award. July 2013- Poster presentation at The 27th Annual Symposium of The Protein Society, Boston, MA, USA. (July 20–23).
  • Invited talk in the "EMBO workshop on Evolution in the Time of Genomics", Organized by European Molecular Biology Organization, Venice, Italy. 7-9 May, 2012.
  • Awarded fellowship from 'Istituto Pasteur - Fondazioni Cenci Bolognetii, Rome, Italy'
  • Awarded with International Fellowship of Sapienza University of Rome during PhD in Biochemistry.
  • Awarded Junior Research Fellowship from CSIR-UGC (Govt. of India).
  • GATE 2007 in Life Sciences.


Journal Publications (published)
  • Kumar, A, Liang B, Aarthy M, Singh S, Garg N, Mysorekar I, Giri R*. • Hydroxychloroquine inhibits Zika virus NS2B-NS3 protease. ACS Omega. 2018, 3, 18132-18141.(* Corresponding author)
  • Singh A,Kumar A, Uversky VN*, Giri R*. • Understanding the interactability of chikungunya virus proteins via molecular recognition feature analysis. RSC Advances.. 2018,8, 27293-27303.(* Corresponding author)
  • Singh A, Kumar A, Yadav R, Uversky VN, Giri R*. • Deciphering the dark proteome of Chikungunya virus. Scientific Reports. 2018 Apr 11;8(1):5822.(* Corresponding author)
  • Murali A, Kumar D, Giri R ,Singh S K. E7 oncoprotein of human papillomavirus: Structural dynamics and inhibitor screening study. Gene. 2018 (in Press).
  • Kalita J, Shukla R, Shukla H, Gadhave K, Giri R , Tripathi T. Comprehensive analysis of the catalytic and structural properties of a mu-class glutathione s-transferase from Fasciola gigantica. Sci Rep. 2017 Dec 13 doi: 10.1038/s41598-017-17678-3.
  • Mishra PM, Uversky VN*, Giri R*. Molecular Recognition Features in Zika Virus Proteome. Journal of Molecular Biology. 2017 November 7 doi: 10.1016/j.jmb.2017.10.018.(* Corresponding Authors)
  • Sharma N, Murali A, Singh SK*, Giri R*. Epigallocatechin gallate, an active green tea compound inhibits the Zika virus entry into host cells via binding the envelope protein. Int J Biol Macromol.. 2017 June 28; 104(Pt A): 1046-1054(* Corresponding Authors)
  • Kumar D, Sharma N and Giri R*. Therapeutic Interventions of Cancers Using Intrinsically Disordered Proteins as Drug Targets: c-Myc as Model System. Cancer Inform. 2017 March 16(* Corresponding Author)
  • Khrustalev VV*, Khrustaleva TA,Sharma N and Giri R*. Mutational Pressure in Zika Virus:Local ADAR-Editing Areas Associated with Pauses in Translation and Replication. Front Cell Infect Microbiol.. 2017 Feb 22;7:44.(* Corresponding Authors)
  • Giri R*, Kumar D, Sharma N, Uversky VN*. Intrinsically Disordered Side of the Zika Virus Proteome. Front Cell Infect Microbiol.. 2016 Nov 4;6:144.(* Corresponding Authors)
  • Camilloni C, Bonetti D, Morrone A, Giri R, Dobson CM, Brunori M, Gianni S, Vendruscolo M. Towards a structural biology of the hydrophobic effect in protein folding. Sci Rep. 2016 Jul 27;6:28285.
  • Toto A, Camilloni C, Giri R, Brunori M, Vendruscolo M, Gianni S. Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein. Sci Rep. 2016 Feb 25;6:21994.
  • Dey G, Gaur P, Giri R*, Ghosh S*. Optical signaling in biofluids: a nondenaturing photostable molecular probe for serum albumins. Chem Commun. 2016 Jan 21;52(9):1887-90. (* Corresponding Authors)
  • VanSchouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg FW, Kim C, Melacini G. " Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).J Biol Chem, 2015 Nov 27;290(48):28631-41.
  • Gianni S, Camilloni C, Giri R , Toto A, Bonetti D, Morrone A, Sormanni P, Brunori M, Vendruscolo M. “Understanding the frustration arising from the competition between function, misfolding and aggregation in a globular protein”. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14141-6.
  • Toto A, Giri R, Brunori M, and Gianni S. " The mechanism of binding of the KIX domain to the Mixed Lineage Leukemia protein and its allosteric role in the recognition of c-Myb ". Protein Sci. 2014;23(7):962-9.
  • Boulton S, Akimoto M, Vanschouwen B, Moleschi K, Selvaratnam R, Giri R, Melacini G. " Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR ". Biochemical Society transactions, 2014, 42(2):302-7.
  • Bonetti D, Toto A, Giri R, Morrone A, Sanfelice D, Pastore A, Temussi P, Gianni S and Brunori M. "The kinetics of folding of frataxin". Physical Chemistry Chemical Physics 2014 Apr 14, 16:6391-7.
  • Giri R, Travaglini-Allocatelli C, Gianni S, Giardina G and Brunori M. ""Morphogenesis of proteins: classic views and challenges ahead". Journal of Proteins and Proteomics, 2013.
  • Giri R, Morrone A, Toto A, Brunori M, Gianni S, “Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system”. Proc Natl Acad Sci U S A. 2013,110(37):14942-7.
  • Gianni S , Morrone A , Giri R , Brunori M, "A folding-after-binding mechanism describes the recognition between the transactivation domain of c-Myb and the KIX domain of the CREB-binding protein.", Biochemical and biophysical research communications, 2012, 428(2).
  • Morrone A , Giri R , Brunori M , Gianni S, "Reassessing the folding of the KIX domain: evidence for a two-state mechanism.", Protein science , 2012, 21(11).
  • Giri R , Morrone A , Travaglini-Allocatelli C , Jemth P , Brunori M , Gianni S, "Folding pathways of proteins with increasing degree of sequence identities but different structure and function.", Proc Natl Acad Sci U S A. 2012;109(44):17772-6.
  • Brunori M , Gianni S , Giri R , Morrone A , Travaglini-Allocatelli C, "Morphogenesis of a protein: folding pathways and the energy landscape.", Biochemical Society Transactions, 2012, 40(2).
  • Morrone A , Giri R , Toofanny RD , Travaglini-Allocatelli C , Brunori M , Daggett V , Gianni S, "GB1 is not a two-state folder: identification and characterization of an on-pathway intermediate.", Biophysical Journal, 2011, 101(8).
  • Conferences and Symposia

    • February 2015: Invited lecture in the National Symposium on Biophysics & Golden Jubilee Meeting of Indian Biophysical Society, New Delhi, India. (February 14-17).
    • July 2013- Poster presentation at The 27th Annual Symposium of The Protein Society, Boston, MA, USA. (July 20–23). Awarded with Protein Science Young Investigator Travel Grant / Protein Society Finn Wold Travel Award.
    • May 2012- Oral and poster presentation at the EMBO workshop on “Evolution in the time of genomics”, EMBO, Venice, Italy. (May 7-9)
    • June 2011- Poster presentation in the FEBS symposium on “Biochemistry for tomorrow’s medicine”, FEBS, Turin, Italy. (June 25-30)
    • December 2010- Participation in the International symposium on “Protein Structure and Dynamics”, Accademia Nazionale dei Lincei, Rome, Italy. (December 1-3)
    • November 2008- I participated in National seminar and workshop on “METABOLIC NETWORKS AND DRUG DESIGNING” organized by Dept. of Biotechnology, Government of India, at Varanasi, India. (November 28-30)
    • November 2008- I participated in “4th ASIA OCEANIA CONFERENCE ON PHOTOBIOLOGY” organized by Banaras Hindu University, Varanasi, India. (November 24-26)
    • March 2008- Poster presentation at Indo-Danish symposium, held at University of Delhi (India). (March 17-18)

    Job Opportunities

    • We encourage the applications for postdoctoral positions through National Postdoctoral Programs. Post Doctoral Fellows/Research Associates with their Own Grants/fellowships are welcome to contact via E-mail with your full bio-data, previous works, best three publications and one page write up on the proposed plan.